Researchers from the Hubrecht Institute and Utrecht University developed an advanced technique that makes it possible to monitor a virus infection live. The researchers from the groups of Marvin Tanenbaum and Frank van Kuppeveld expect that the technique can be used to study a wide variety of viruses, including SARS-CoV-2 – the virus responsible for the current pandemic. The technique named VIRIM (‘virus infection real-time imaging’) is therefore very valuable for gaining insights in virus infection in the human body. Eventually, this can lead to more targeted treatments for viral infection.
A biologist with a background in social psychology. Or: science geek with a passion for communication. In any case: experienced science communicator with an interest in outreach and public engagement.
The blood–brain barrier (BBB) is a complex multicellular structure forming a protective layer of tightly joined polarized cells, that separate the central nervous system (CNS) from the systemic circulation. To break down this barrier a variety of approaches of drug delivery into the brain exist, but unfortunately they mostly cause severe side effects. Hence, the overall goal is to find an appropriate way of a non-invasive and highly efficient targeted drug delivery into the brain. We are currently investigating a new harmless approach of nanobody (NB)-mediated receptor internalization and subsequent directed transcytosis within polarized brain endothelial cells (BECs). We use phage selection to receive NBs, which are targeting the ectodomain of the heparin-binding EGF-like growth factor (HB-EGF) receptor, that is known to be transcytosed and constitutively expressed at the cell surface on the abluminal side of BECs.
fangrui chen
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Company
UU, Faculty of Science
Job title
PhD student
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Ruben Schmidt
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UU, Faculty of Science
Job title
Ressearch assistant
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Jannes Kromhout
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Utrecht University
Job title
Master student
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Esther Nolte-'t Hoen
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Company
UU, Faculty of Veterinary Medicine
Job title
Assistant Professor
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Laura Hofman
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Princess Maxima Center for Pediatric Oncology
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Master student
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Xinyi Pei
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UU, Faculty of Veterinary Medicine
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PhD student
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Victoria Castiglioni
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UU, Faculty of Science
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PhD student
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Babet van der Vaart
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UU, Faculty of Science
Job title
Postdoc
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Microtubule cytoskeleton
About me
I am studying the microtubule cytoskeleton and protein trafficking in hiPSC-derived cardiomyocytes.
Carla Pou Casellas
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Hubrecht Institute
Job title
PhD student
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Ada Annala
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UU, Faculty of Science
Job title
PhD student
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Erik Hebels
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Utrecht University
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PhD Candidate
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Ieva Cesonyte
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UU, Faculty of Veterinary Medicine
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PhD student
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Robert Jan Lebbink
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Company
UMCU
Job title
Assistant professor
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Jeroen Bugter
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Company
UMC Utrecht
Job title
PhD student
Interests
colorectal cancer; WNT signaling; functional validations of cancer driver mutations; organoids
About me
Madelon Maurice
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UMC Utrecht
Job title
Professor
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Susanne Grein
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UU, Faculty of Veterinary Medicine
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Postdoc
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Boris Shneyer
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UU, Faculty of Science
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Postdoc
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Boning Qiu
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UU, Faculty of Science
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PhD student
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Dennis Doorduijn
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UMC Utrecht
Job title
PhD candidate
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Maarten Huismans
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UMC Utrecht
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PhD student
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ive logister
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Company
Hubrecht Institute
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Technician
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Hannah Johnson
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Company
Princess Maxima Center for Pediatric Oncology
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Technician
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Ludo Westerveld
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NEMO Science Museum
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Programmamaker
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Wenjuan Du
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UU, Faculty of Veterinary Medicine
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Postdoc
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Isabel Arends
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Faculteit Bètawetenschappen / Science
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Hoogleraar / Professor
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Anke Hammerschlag
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Coordinator doctoral education Graduate School of Life Sciences
Clinical Embryologist at the Department of Clinical Sciences of the Faculty of Veterinary Medicine.
Research interests: understanding the origin of aneuploidy in oocytes and early embryos
