Using computer simulations to discover how proteins engage with genomic DNA
Transcription Factors are the proteins that regulate the gene expression, meaning that they control complex processes such as cellular differentiation, development, morphogenesis, and changes in the cell behavior. A particular subset of Transcription Factors, called pioneer Transcription Factors can do their function in the so-called “closed chromatin”: Areas of the cell nucleus where the DNA is heavily compacted. Using molecular dynamics simulations, we are able to study how a pioneer Transcription Factor, Oct4, binds and interacts with closed chromatin.
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Jan Huertas
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Hubrecht Institute
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PhD Student
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About me
Born in Barcelona.
I studied Human Biology at the Pompeu Fabra University, in Barcelona, where I also cursed my masters in Bioinformatics.
Currently I'm at the Max Planck Institute for Biomedicine, in Münster, Germany, finishing my PhD under the supervision of Vlad Cojocaru (Hubrecht Institute)
