The sino-nasal warzone: transcriptomic and genomic studies on sino-nasal aspergillosis in dogs
Dogs with chronic non-invasive sino-nasal aspergillosis are infected with a single genotype of Aspergillus fumigatus. We studied transcriptomes of fungal pathogen and the host of dogs with natural fungal infections. We show absence of a Th17 response and dampening of the Th1 response which contributes to the formation of a chronic sino-nasal warzone. Fungus and host are in a battle for metals. The fungus adapts to the host during growth resulting in large genetic and phenotypic variation reflecting in-host adaptation.
Hans de Cock studied biology (B4, chemical biology) at Utrecht University (UU) (1980-1986). He performed his graduate research in Molecular Microbiology at UU and received his Ph.D. in 1991 with his thesis entitled: "Biogenesis of outer membrane protein PhoE of Escherichia coli K-12: studies on protein conformation” He worked as NWO postdoctoral fellow in the Biochemistry and Biophysics laboratory with Prof. dr. Linda Randall at Washington State University in Pullman, USA on protein folding. In 1992, he became Fellow of the Royal Academy of Arts and Sciences of the Netherlands and assistant professor at Molecular Microbiology at the UU and worked till 2003 on bacterial protein and lipid transport and subsequently on fungal infection due to Cryptococcus and since 2010 due to Aspergillus
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