The sino-nasal warzone: transcriptomic and genomic studies on sino-nasal aspergillosis in dogs

Dogs with chronic non-invasive sino-nasal aspergillosis are infected with a single genotype of Aspergillus fumigatus. We studied transcriptomes of fungal pathogen and the host of dogs with natural fungal infections. We show absence of a Th17 response and dampening of the Th1 response which contributes to the formation of a chronic sino-nasal warzone. Fungus and host are in a battle for metals. The fungus adapts to the host during growth resulting in large genetic and phenotypic variation reflecting in-host adaptation.

16-11-2020 15:15 - 15:30